Identification of new bioactive compounds; hyphenated techniques

Image The second objective of this research line is the identification, characterization and study of the biological activity of diverse natural sources of bioactive compounds with potential application in the treatment or prevention of obesity and its associated comorbidities. These bioactive compounds are of great interest for both the food and the pharmaceutical industry, as they can be the basis for the development of new dietary supplements or functional foods. To this end, activity studies of new extracts or molecules are developed in various models (in vitro, C. elegans, rat / mouse, etc.)... Read More

Monoclonal antibodies in multiple myeloma therapy

Image Multiple myeloma (MM) results from the proliferation of a malignant plasma cell and frequently leads to complications such as lytic bone disease, hypercalcemia, renal failure, and impaired immunity. Over the past 2 decades, progression-free survival (PFS) and overall survival for MM have more than doubled, largely due to improvements in therapy with the addition of novel agents such as immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs).  The understanding of MM pathobiology has undergone a similar period of growth, leading to the discovery of novel targets ... Read More

Chromatography is the most widely used separation technique in chemical laboratories

Image Chromatography is the most widely used separation technique in chemical laboratories, where it is used in analysis, isolation and purification, and it is commonly used in the chemical process industry as a component of small and large-scale production. In terms of scale, at one extreme minute quantities of less than a nanogram are separated and identified during analysis, while at the other, hundreds of kilograms of material per hour are processed into refined products. It is the versatility of chromatography in its many variants that is behind its ubiquitous status in separation science, c... Read More

New Therapies and Immunological Findings in Melanoma and other Skin Cancers

Image Now-a-days, dermatologists and immunologists are striving hard to develop new therapies in the field of skin cancer. In particular, immunological findings have led to the development of highly effective immune-checkpoint inhibitors for cancer. Hence, they are being highlighted and improvised in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments. ... Read More