This study set out to assess the levels, distribution and human health risk of Pb, As, Cd, Mn and polycyclic aromatic hydrocarbons (PAHs) in sediments from the Fosu Lagoon in Ghana. This was coupled with environmental fate modeling to investigate biodegradation behaviour of PAHs in sediment. Generally, the order of heavy metal enrichment for the sampling locations was Mn>Cd>Pb>As respectively. Only Mn showed significant enrichment at all sites. The observed PAH contamination demonstrated potential anthropogenic impact. The phenanthrene-anthracene ratio was less than 10 indicating that the PAHs originate from combustion.